ELK Biotechnology Chk1 (phospho Ser345) rabbit pAb
Chk1 (phospho Ser345) rabbit polyclonal antibody로, DNA 손상 반응 및 세포주기 조절 연구에 적합합니다. IHC, IF, ELISA에 사용 가능하며 인산화된 Ser345 부위를 인식합니다. 사람, 생쥐, 랫드에 반응하며 -20°C에서 1년 보관 가능합니다.
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제품명
Chk1 (phospho Ser345) rabbit pAb
제품 개요
Chk1 단백질은 DNA 손상 반응 및 세포주기 조절에 관여하는 Ser/Thr 단백질 키나아제입니다. 본 항체는 인산화된 Ser345 부위를 인식하는 rabbit polyclonal antibody로, 다양한 생물학적 연구에 활용할 수 있습니다.
제품 정보
| 항목 | 내용 |
|---|---|
| Product name | Chk1 (phospho Ser345) rabbit pAb |
| Alternative Names | CHEK1; CHK1; Serine/threonine-protein kinase Chk1; CHK1 checkpoint homolog; Cell cycle checkpoint kinase; Checkpoint kinase-1 |
| Applications | IHC; IF; ELISA |
| Recommended Dilutions | Immunohistochemistry: 1/100 - 1/300 ELISA: 1/10000 Not yet tested in other applications |
| Immunogen | Synthesized peptide derived from human Chk1 around the phosphorylation site of Ser345 (AA range: 310–359) |
| Host | Rabbit |
| Storage | -20°C / 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| GeneID (Human) | 1111 |
| Human Swiss-Prot No | O14757 |
| Cellular Localization | Nucleus, Chromosome, Cytoplasm, Centrosome. Nuclear export mediated partly by XPO1/CRM1. Localizes to centrosome during interphase and protects CDC2 kinase from inappropriate activation by CDC25B. Proteolytic cleavage by SPRTN promotes removal from chromatin. |
| Species Reactivity | Human; Mouse; Rat |
Background
The protein encoded by this gene belongs to the Ser/Thr protein kinase family. It is required for checkpoint-mediated cell cycle arrest in response to DNA damage or unreplicated DNA. It integrates signals from ATM and ATR, key proteins in DNA damage responses, and associates with chromatin in meiotic prophase I. Phosphorylation of CDC25A by Chk1 is essential for delaying cell cycle progression following double-strand DNA breaks. Several alternatively spliced transcript variants have been identified for this gene (RefSeq, Oct 2011).
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