ELK Biotechnology VE-Cadherin (phospho Tyr731) rabbit pAb
VE-Cadherin (phospho Tyr731) rabbit polyclonal antibody로, 인산화된 VE-Cadherin 단백질 검출에 적합합니다. WB, IHC, IF, ELISA에 사용 가능하며, 세포 간 접합부 연구에 유용합니다. 사람 및 생쥐 시료에 반응합니다.
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제품명
VE-Cadherin (phospho Tyr731) rabbit pAb
제품 정보
| 항목 | 내용 |
|---|---|
| Alternative Names | CDH5; Cadherin-5; 7B4 antigen; Vascular endothelial cadherin; VE-cadherin; CD antigen CD144 |
| Applications | WB; IHC; IF; ELISA |
| Recommended Dilutions | Western Blot: 1/500 - 1/2000 Immunohistochemistry: 1/100 - 1/300 ELISA: 1/20000 Not yet tested in other applications |
| Immunogen | The antiserum was produced against synthesized peptide derived from human VE-Cadherin around the phosphorylation site of Tyr731. (AA range: 697–746) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Observed Band | 130 kDa |
| Gene ID (Human) | 1003 |
| Human Swiss-Prot No | P33151 |
| Species Reactivity | Human; Mouse |
| Cellular Localization | Cell junction; Cell membrane; Single-pass type I membrane protein. Found at cell-cell boundaries and probably at cell-matrix boundaries. KRIT1 and CDH5 reciprocally regulate their localization to endothelial cell-cell junctions. |
Background
This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is composed of five extracellular cadherin repeats, a transmembrane region, and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. (RefSeq, Nov 2015)
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