Thermo Fisher Scientific PRMT6 Recombinant Rabbit Monoclonal Antibody (8H9L19)
PRMT6 단백질을 인식하는 재조합 토끼 단클론 항체로 높은 특이성과 민감도를 제공. ICC/IF 및 ChIP assay에 적합하며, 인간 및 여러 종에서 반응 예측. 일관된 로트 품질과 동물 유래 성분 없는 제형으로 연구용에 최적화.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | 1:100 |
| ChIP assay (ChIP) | 2.5 µg/million cells |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 8H9L19 |
| Immunogen | Peptides corresponding to human PRMT6 (aa37–aa49, aa358–aa375) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2809240 |
Product Specific Information
This antibody is predicted to react with Monkey, Pig, Rat, and Cat.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. Specific antibody DNA sequences from immunoreactive rabbits are cloned and screened to select the best candidates for production.
Advantages of recombinant rabbit monoclonal antibodies:
- Better specificity and sensitivity
- Lot-to-lot consistency
- Animal origin-free formulations
- Broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
Target Information
Protein arginine N-methyltransferase 6 (PRMT6):
PRMT6 demonstrates type I PRMT activity, forming both omega-N monomethylarginine and asymmetric dimethylarginine derivatives on recombinant glycine- and arginine-rich substrates.
Acts as a transcriptional coactivator of steroid hormone receptors including ESR1, ESR2, PGR, and NR3C1.
Promotes fasting-induced transcriptional activation of the gluconeogenic program through methylation of the CRTC2 transcription coactivator.
May contribute to innate immunity against HIV-1 by methylating and impairing the function of viral proteins such as Tat, Rev, and Nucleocapsid protein p7.
For Research Use Only.
Not for use in diagnostic procedures. Not for resale without express authorization.
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