Thermo Fisher Scientific PRRX1 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:50-1:200

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Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to amino acids 100-145 of Human PRRX1. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:PRRX1,uniProtId:P54821-1,ncbiNodeId:9606,antigenRange:100-145,antigenLength:245,antigenImageFileName:PA5-75553_PRRX1_P54821-1_Rabbit.svg,antigenImageFileNamePDP:PA5-75553_PRRX1_P54821-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.2, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Wet ice

RRID

AB_2719281

Product Specific Information

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

Target Information

The homeobox DNA-binding domain is a 60 amino acid motif that is conserved among many species and functions to bind DNA via a helix-turn-helix structure, thereby playing a role in transcriptional regulation and the control of gene expression. PRX1 (paired related homeobox 1), also known as PRRX1, PMX1 or PHOX1, is a 245 amino acid protein that contains one OAR domain and one homeobox DNA-binding domain and belongs to the paired homeobox family. Localized to the nucleus, PRX1 functions as a transcriptional co-activator that enhances the DNA-binding activity of serum response factor (SRF), thereby mediating the induction of SRF-dependent gene expression by growth and differentiation factors. Additionally, PRX1 regulates the transcriptional activities of creatine kinase-M (muscle), thereby playing a role in the establishment of mesodermal muscle types. PRX1 exists as two alternatively spliced isoforms, designated PMX1-A and PMX1-B.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.