Thermo Fisher Scientific PRRX1 Polyclonal Antibody
PRRX1 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot 및 Immunocytochemistry에 적합하며, 항원 친화 크로마토그래피로 정제됨. 고순도(>95%) 액상 형태로 제공되며, 연구용으로 사용.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
- View 1 publication
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1:50–1:200
- View publication
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 100–145 of Human PRRX1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2719281 |
Product Specific Information
The antibody was affinity-purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. The purity is >95% (by SDS-PAGE).
Target Information
The homeobox DNA-binding domain is a 60 amino acid motif conserved among many species, functioning to bind DNA via a helix-turn-helix structure for transcriptional regulation.
PRX1 (paired related homeobox 1), also known as PRRX1, PMX1, or PHOX1, is a 245 amino acid protein containing one OAR domain and one homeobox domain.
Localized to the nucleus, PRX1 acts as a transcriptional co-activator enhancing the DNA-binding activity of serum response factor (SRF), mediating SRF-dependent gene expression.
Additionally, PRX1 regulates transcriptional activities of creatine kinase-M (muscle), contributing to mesodermal muscle type establishment.
PRX1 exists as two alternatively spliced isoforms: PMX1-A and PMX1-B.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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