Thermo Fisher Scientific Human ATP2C2 Synthetic Peptide
인간 ATP2C2의 아미노 말단 19개 아미노산 서열을 기반으로 한 합성 펩타이드. PA5-21127 항체의 블로킹 펩타이드로 사용 가능. 정제된 액상 형태, PBS 버퍼에 0.1% BSA 및 0.02% sodium azide 포함. 연구용으로만 사용.
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Thermo Fisher Scientific Human ATP2C2 Synthetic Peptide
Applications
- Control (Ctrl): Assay-dependent
- Blocking Assay (BLOCK): Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Class | Synthetic |
| Type | Peptide |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Purified |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human ATP2C2.
PEP-1241 can be used as a blocking peptide with polyclonal antibody PA5-21127.
Target Information
ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.
Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles.
Unlike ATP2C1, ATP2C2 has a more restricted expression pattern, higher maximal turnover rate for overall Ca²⁺-ATPase reaction, and lower apparent affinity for cytosolic Ca²⁺ activation of phosphorylation.
Overexpression of ATP2C2 in mammary tumors results in Ca²⁺ influx via the store-operated Ca²⁺ channel ORAI1, independent of STIM1 and STIM2 sensors.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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