Thermo Fisher Scientific Human ATP2C2 Synthetic Peptide

Thermo Fisher Scientific Human ATP2C2 Synthetic Peptide

Applications

• Control (Ctrl): Assay-dependent
• Blocking Assay (BLOCK): Assay-dependent

Product Specifications

Product Specific Information

This peptide corresponds to 19 amino acids near the amino terminus of human ATP2C2.
PEP-1241 can be used as a blocking peptide with polyclonal antibody PA5-21127.

Target Information

ATP2C2, also known as secretory pathway Ca²⁺/Mn²⁺-ATPase (SPCA2), belongs to the family of P-type cation transport ATPases.
This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium from the cytosol to the Golgi lumen.
Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles.
Unlike ATP2C1, ATP2C2 has a more restricted expression pattern, higher maximal turnover rate for overall Ca²⁺-ATPase reaction, and lower apparent affinity for cytosolic Ca²⁺ activation of phosphorylation.
Overexpression of ATP2C2 in mammary tumors results in Ca²⁺ influx via the store-operated Ca²⁺ channel ORAI1, independent of STIM1 and STIM2 sensors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.