Thermo Fisher Scientific TRADD Polyclonal Antibody
TRADD 단백질을 인식하는 Rabbit Polyclonal 항체로, Human, Mouse, Rat 시료에 반응합니다. Western blot, IHC, ICC/IF에 적합하며, 고순도의 Affinity chromatography 정제 항체입니다. 세포 사멸 및 TNF 신호전달 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
| Immunocytochemistry (ICC/IF) | 1:100–1:500 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human TRADD (Accession Q15628), corresponding to amino acid residues M1–A31 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Wet ice |
| RRID | AB_2854533 |
Product Specific Information
This antibody detects endogenous levels of total TRADD.
Target Information
TRADD (Tumor necrosis factor receptor type 1-associated DEATH domain protein) is a key mediator in FAS and TNFR1-associated apoptotic signaling. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12. TRADD interacts with TRIP12, disrupting its interaction with p19ARF/ARF, and serves as an adapter molecule for TNFRSF1A/TNFR1, mediating its interaction with FADD. Overexpression of TRADD leads to TNF-induced apoptosis and NF-kappa-B activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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