Thermo Fisher Scientific Torc1 Monoclonal Antibody (2D4)

Applications

• Western Blot (WB): 1:1,000–1:2,000

Product Specifications

Product Specific Information

This antibody was affinity-purified from mouse ascites by antigen-specific affinity chromatography. The purity is greater than 95% as determined by SDS-PAGE.

Target Information

TORC1 acts as a transcriptional coactivator for CREB1, activating transcription through both consensus and variant cAMP response element (CRE) sites. It functions as a coactivator in the SIK/TORC signaling pathway, being active when dephosphorylated, and acts independently of CREB1 Ser-133 phosphorylation. TORC1 enhances CREB1 interaction with TAF4 and regulates expression of CREB-activated genes such as StAR. It is a potent coactivator of PGC1α and an inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, TORC1 contributes to late-phase long-term potentiation (L-LTP) maintenance at Schaffer collateral-CA1 synapses and may be required for dendritic growth of developing cortical neurons. Together with SIK1, it regulates light-induced entrainment of the circadian clock by coactivating CREB-mediated transcription of PER1, a key gene in photic entrainment.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.