Thermo Fisher Scientific HNMT Monoclonal Antibody (2G12)
HNMT 단백질을 인식하는 마우스 단클론 항체(2G12)로, Western blot 및 ELISA에 적합합니다. 비결합형 액상 제품이며, 인간 시료에 반응합니다. 연구용으로만 사용되며, -20°C에서 보관하십시오.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
ELISA
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G12 |
| Immunogen | HNMT (NP_008826, 184 a.a. ~ 292 a.a) partial recombinant protein with GST tag (MW of GST tag: 26 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | See Label |
| Storage Buffer | Ascites |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Sequence of this protein is as follows:
KKYGSRFPQD DLCQYITSDD LTQMLDNLGL KYECYDLLST MDISDCFIDG NENGDLLWDF LTETCNFNAT APPDLRAELG KDLQEPEFSA KKEGKVLFNN TLSFIVIEA
Target Information
Histamine in mammals is metabolized via two major pathways:
- N(tau)-methylation through histamine N-methyltransferase (HNMT)
- Oxidative deamination via diamine oxidase
HNMT functions in the cytosol, using S-adenosyl-L-methionine as the methyl donor. In the brain, histamine neurotransmitter activity is regulated by N(tau)-methylation, as diamine oxidase is absent in the central nervous system. A common genetic polymorphism can affect HNMT activity levels in red blood cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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