Thermo Fisher Scientific HNMT Monoclonal Antibody (2G24)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1:500-1:1,000

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG3, kappa

Class

Monoclonal

Type

Antibody

Clone

2G24

Immunogen

HNMT (NP_008826, 184 a.a. approximately 292 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:HNMT,uniProtId:P50135-1,ncbiNodeId:9606,antigenRange:184-292,antigenLength:292,antigenImageFileName:H00003176-M12A_HNMT_P50135-1_House_mouse.svg,antigenImageFileNamePDP:H00003176-M12A_HNMT_P50135-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

See Label

Storage buffer

ascites

Contains

no preservative

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Sequence of this protein is as follows: KKYGSRFPQD DLCQYITSDD LTQMLDNLGL KYECYDLLST MDISDCFIDG NENGDLLWDF LTETCNFNAT APPDLRAELG KDLQEPEFSA KKEGKVLFNN TLSFIVIEA

Target Information

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. HNMT is the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.