Thermo Fisher Scientific Phospho-Pdcd4 (Ser457) Polyclonal Antibody
Phospho-Pdcd4 (Ser457) 특이성을 가진 Rabbit Polyclonal 항체로, Human, Mouse, Rat, Xenopus에 반응합니다. Western blot, IHC, ELISA에 적합하며, 액상 형태로 1 mg/mL 농도입니다. Apoptosis 관련 PDCD4 단백질 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 21.25–2.5 µg/mL |
| ELISA | 1:400,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat, Xenopus |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Affinity purified antibody prepared from whole rabbit serum immunized with a synthetic peptide corresponding to amino acids surrounding Ser457 in the human Pdcd4 protein. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | 0.02M potassium phosphate, pH 7.2, with 0.15M NaCl |
| Contains | 0.01% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Store vial at −20°C prior to opening. Aliquot contents and freeze at −20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. Stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use.
This antibody is specific for human Pdcd4 protein phosphorylated at Ser457. BLAST analysis suggests cross-reactivity with Pdcd4 from human, mouse, rat, and Xenopus based on 100% homology with the immunizing sequence. Cross-reactivity with Pdcd4 from other sources has not been determined.
Target Information
Apoptosis, or programmed cell death, is essential for development, tissue turnover, and tumor formation. PDCD4 (Programmed Cell Death Protein 4) expression increases during apoptosis and encodes a tumor suppressor protein lost in several carcinomas (breast, colon, lung, prostate). PDCD4 inhibits the helicase activity of eIF4A and suppresses AP-1-mediated transcriptional activation. Akt kinase phosphorylates PDCD4, reducing its ability to interfere with AP-1 transactivation. Two isoforms of PDCD4 are known.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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