Thermo Fisher Scientific SLUG Polyclonal Antibody
SLUG 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체. Western blot과 IHC에서 사용 가능하며 인간과 마우스 반응성이 높음. 항원 친화 크로마토그래피로 정제된 고농도 액상 항체로 연구용에 적합.
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Applications
Western Blot (WB)
- Tested Dilution: 1:1,000–1:10,000
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: 1:100–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein encompassing a sequence within the center region of human SLUG |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | 0.1M Tris glycine, pH 7, with 20% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2792618 |
Product Specific Information
- Keep as concentrated solution.
- Predicted Reactivity: Mouse (100%), Rat (99%), Zebrafish (93%), Xenopus laevis (97%), Dog (100%), Pig (97%), Sheep (95%), Rhesus Monkey (100%), Bovine (96%).
- Positive Control: human SNAI2-transfected 293T cells.
- Centrifuge briefly prior to opening the vial.
Target Information
Slug, a member of the Snail family of C2H2-type zinc finger transcription factors, is involved in epithelial-mesenchymal transitions and neural tube formation during vertebrate embryogenesis.
Its transcription can be induced by growth factors such as FGF, BMP, and TGF-beta. Slug binds E-box regions of promoters and represses transcription of genes including E-cadherin and Claudin-1.
Expression in breast, esophageal, and colorectal carcinomas correlates with poor prognosis.
Slug also protects hemopoietic progenitor cells from radiation-induced apoptosis by repressing p53-mediated transcription of Puma.
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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