Thermo Fisher Scientific CD45 Monoclonal Antibody (HI30), Pacific Blue

Applications

Flow Cytometry (Flow)

• Tested Dilution: Assay-dependent
• Publications: View 5 publications

Miscellaneous PubMed (Misc)

• Publications: View 1 publication

Product Specifications

Additional Conjugate Formats

• Alexa Fluor 405
• Alexa Fluor 488
• Alexa Fluor 700
• APC
• APC-Alexa Fluor 750
• Biotin
• FITC
• Pacific Orange
• PE
• PE-Alexa Fluor 610
• PE-Cyanine5.5
• PE-Cyanine7
• PE-Texas Red
• PerCP
• Qdot 605
• Qdot 655
• Qdot 800
• TRI-COLOR
• Request custom conjugation available

Product Specific Information

The Mouse anti-Human CD45 Monoclonal Antibody (HI30) recognizes the CD45 antigen, which is expressed on all cells of hematopoietic origin except platelets and red blood cells and their immediate precursors. CD45 is considered a pan-leukocyte marker.
For this Pacific Blue™ conjugate: Excitation/Peak Emission (nm) = 405/455.

Target Information

CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) expressed on all nucleated hematopoietic cells, comprising about 10% of surface proteins in lymphocytes. It is absent on non-hematopoietic tissues and cell lines.
CD45 plays a crucial role in lymphocyte development and antigen signaling, regulating Src-family kinases and cytokine receptor signaling. It also contributes to cell survival, integrin-mediated signal transduction, and modulation of immunological functions.
Multiple isoforms of CD45 exist due to alternative splicing, differing in extracellular domains but sharing transmembrane and cytoplasmic regions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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