Thermo Fisher Scientific CYLD Monoclonal Antibody (2G1)

Applications

• ELISA (ELISA)
  Tested Dilution: 10 µg/mL

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
QNMELFAVLC IETSHYVAFV KYGKDDSAWL FFDSMADRDG GQNGFNIPQV TPCPEVGEYL KMSLEDLHSL DSRRIQGCAR RLLCDAYMCM YQSPTMSLYK

Target Information

CYLD is a 956 amino acid cytoplasmic deubiquitinating enzyme of the ubiquitin carboxy-terminal hydrolases (UCH) family. It contains three CAP-GLY domains, a proline-rich region, an SH3 binding domain, and a catalytic domain homologous to UCH.
CYLD functions as a tumor suppressor affecting the JNK signaling pathway and negatively regulates TRAF2 and NF-kappa-B signaling. It also plays a role in I-kappa-B kinase pathway regulation and exhibits deubiquitinating activity toward non-Lys-48-linked polyubiquitin chains. TRAP1 is identified as a novel substrate.
Mutations in CYLD are associated with cylindromatosis, multiple familial trichoepithelioma, and Brooke-Spiegler syndrome.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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