Thermo Fisher Scientific PSMB8 Polyclonal Antibody, Alexa Fluor 488
인간 PSMB8 단백질을 인식하는 Rabbit Polyclonal 항체로, Alexa Fluor 488 형광 표지. ICC/IF 실험에 적합하며, 499/520 nm의 여기/방출 특성. 항원 친화 크로마토그래피로 정제되어 높은 특이성과 안정성 제공.
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Applications
Immunocytochemistry (ICC/IF)
- Tested Dilution: 1–10 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic Peptide: C V(259) E S T D V S D L L H Q Y R E A(274) |
| Conjugate | Alexa Fluor™ 488 |
| Excitation / Emission Max | 499 / 520 nm |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.4, with 1 mg/mL BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2662739 |
Product Specific Information
PA1972A488 detects proteasome 20S LMP7 from human cells.
The immunizing peptide corresponds to amino acid residues 259–274 from human proteasome 20S LMP7 protein.
This sequence is completely conserved between human, mouse, rat, and sheep.
PA1972A488 immunizing peptide (Cat. # PEP-132) is available for use in neutralization and control experiments.
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered 20S core structure composed of 4 rings containing 28 non-identical subunits (7 alpha and 7 beta per ring).
Proteasomes are abundant in eukaryotic cells and cleave peptides in an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome processes class I MHC peptides.
PSMB8 encodes a member of the proteasome B-type (T1B) family, a 20S core beta subunit located in the MHC class II region.
Expression is induced by gamma interferon, replacing the beta 5 catalytic subunit in the immunoproteasome.
Proteolytic processing generates the mature subunit. Two alternative transcripts encode isoforms that yield the same mature subunit.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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