Thermo Fisher Scientific TRPV1 (VR1) (extracellular) Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Reconstitution: 25 µL, 50 µL, or 0.2 mL double distilled water (DDW), depending on sample size
• Ships as lyophilized powder at room temperature
• Store at -20°C upon arrival
• Reconstituted solution can be stored at 4°C for up to 1 week
• For long-term storage, aliquot and store at -20°C
• Avoid multiple freeze/thaw cycles
• Centrifuge all antibody preparations before use (10,000 × g for 5 min)

Target Information

TRPV1 (Transient Receptor Potential Cation Channel Subfamily V Member 1) is a receptor for capsaicin, the main pungent ingredient in hot chili peppers, and elicits a sensation of burning pain by selectively activating sensory neurons.
It is a non-selective cation channel related to TRP family members such as TRPC3 and TRPC6, permeable to calcium, magnesium, sodium, and potassium ions.
Structurally, TRPV1 contains six transmembrane domains, a P-loop membrane domain, and three ankyrin repeat domains.
TRPV1 is activated by noxious heat and functions as a transducer of painful thermal stimuli. It mediates proton influx and may contribute to intracellular acidosis in nociceptive neurons.
Expression is mainly in sensory ganglia neurons.
Diseases associated with TRPV1 include Irritable Bowel Syndrome (IBS) and Bladder Disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.