Thermo Fisher Scientific IL-19 Polyclonal Antibody, Biotin

Applications

Tested Dilution

Publications

Western Blot (WB)

0.1-0.2 µg/mL

-

ELISA (ELISA)

0.25-1 µg/mL

-

Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant human IL-19

Conjugate

Biotin Biotin Biotin

Form

Lyophilized

Concentration

0.1 mg/mL

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.2

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2280190

Product Specific Information

Reconstitute with 0.5 mL PBS containing 0.1% BSA. For long term storage the addition of 0.09% sodium azide is recommended. Prior to reconstitution, store at 4ºC. After reconstitution, store undiluted at -20ºC, avoiding freeze/thaw cycles.

Rabbit anti Human Interleukin-19 antibody recognizes human IL-19 (interleukin-19), a 153 amino acid secreted helical cytokine belonging to the IL-10 family of regulatory cytokines, which is preferentially expressed in monocytes, but also expressed in B cells, and up-regulated in monocytes stimulated with lipopolysaccharide (LPS) or granulocyte-macrophage colony-stimulating factor (GM-CSF).

Target Information

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.