Thermo Fisher Scientific TRPA1 Polyclonal Antibody
인간 TRPA1 단백질을 인식하는 Rabbit Polyclonal 항체로, 면역조직화학(IHC)에서 10–20 µg/mL 농도로 사용 가능. KLH 결합 합성 펩타이드로 면역화되어 제작됨. 통증 및 염증 관련 연구에 적합하며, 고순도 Affinity chromatography 정제 제품.
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Thermo Fisher Scientific TRPA1 Polyclonal Antibody
Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 10–20 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide: internal domain of human TRPA1, conjugated to Keyhole Limpet Hemocyanin (KLH) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.7 |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long-term storage, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2209937 |
Product Specific Information
- Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for staining paraffin sections.
- Suggested positive control for IHC applications: spinal cord.
- Rabbit anti-Human TRPA1 antibody detects Transient Receptor Potential A1 (TRPA1), an excitatory cation channel highly expressed in nociceptive neurons and involved in inflammatory pain.
Target Information
TRPA1 is a TRP-related channel responsive to cold temperatures and pungent compounds, playing roles in nociceptor and hair cell transduction. It is associated with transformation in lung epithelia and primarily distributed in sensory neurons. Blocking TRPA1 may be a therapeutic strategy for cold hyperalgesia due to inflammation and nerve damage. TRPA1 protein is also expressed outside the CNS and dysregulated during oncogenic transformation. Structurally, TRPA1 relates to ankyrin and transmembrane proteins, potentially involved in signal transduction and growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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