Thermo Fisher Scientific CD163 Recombinant Mouse Monoclonal Antibody (2A10 (2A10/11))
돼지 CD163 항원을 인식하는 Thermo Fisher Scientific의 재조합 마우스 단일클론 항체로, ICC/IF, Flow Cytometry, ELISA 등에 사용 가능. HEK293 발현 시스템에서 생산되며 Protein A로 정제. 1 mg/mL 농도의 액상 형태로 제공되어 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Immunocytochemistry (ICC/IF) | Assay-dependent |
| Flow Cytometry (Flow) | Assay-dependent |
| ELISA | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Pig |
| Host / Isotype | Mouse / IgG1, lambda |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 2A10 (2A10/11) |
| Immunogen | The original antibody was generated by immunizing BALB/c mice with porcine alveolar macrophages. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
Product Specific Information
This antibody recognizes and binds porcine CD163.
Target Information
CD163 (M130 antigen, Ber-Mac3, Ki-M8, SM4) is a 130 kDa membrane glycoprotein and a member of the scavenger receptor cysteine-rich superfamily. It acts as a receptor for the hemoglobin-haptoglobin complex, protecting tissues from oxidative damage caused by free hemoglobin. CD163 is expressed on monocytes and macrophages, primarily in the late phase of inflammation, and is upregulated by IL-10, IL-6, and dexamethasone. It mediates endocytosis of hemoglobin/haptoglobin complexes and triggers intracellular signaling cascades involving calcium mobilization and secretion of IL6 and CSF1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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