Thermo Fisher Scientific GTPBP2 Polyclonal Antibody
Rabbit polyclonal antibody against human GTPBP2, validated for WB, IHC(P), and ICC/IF. Recombinant protein immunogen, high specificity and purity via antigen affinity chromatography. Supplied in PBS with 40% glycerol, suitable for long-term storage at ...
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Applications and Tested Dilutions
| Application | Tested Dilution | References |
|---|---|---|
| Western Blot (WB) | 0.04–0.4 µg/mL | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:2,500 | - |
| Immunocytochemistry (ICC/IF) | 0.25–2 µg/mL | - |
Product Specifications
| Item | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant protein corresponding to Human GTPBP2. Recombinant protein control fragment (Product #RP-94951). |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.3 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 40% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2642267 |
Product Specific Information
Immunogen sequence:
DGNIEYKLKL VNPSQYRFEH LVTQMKWRLQ EGRGEAVYQI GVEDNGLLVG LAEEEMRASL KTLHRMAEKV GADITVLRER EVDYDSDMPR KITEVLVRKV P
- Highest antigen sequence identity to orthologs:
- Mouse: 99%
- Rat: 100%
Target Information
Small G proteins act as molecular switches regulating various cellular processes such as nuclear transport, signal transduction, membrane trafficking, and protein synthesis.
GTPBP2 (GTP-binding protein 2) is a 602 amino acid G protein expressed in kidney, skeletal muscle, testis, brain, and thymus, but not in liver.
Expression is enhanced by γ-interferon stimulation in HeLa cells, THP-1 cells, and thioglycollate-elicited mouse peritoneal macrophages.
There are four isoforms of GTPBP2 produced by alternative splicing.
GTPBP2 shares 44% sequence similarity with GTPBP1 and overlaps in expression pattern, suggesting potential compensatory roles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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