Thermo Fisher Scientific Nucleophosmin (Acute Myeloid Leukemia Marker) Monoclonal Antibody (NA24)
인체 NPM1 단백질을 인식하는 단클론 항체로, 급성 골수성 백혈병(AML) 마커 연구에 적합합니다. WB, IHC, ICC, Flow 등 다양한 응용 가능. Protein A/G 정제, 액상 형태, 4°C 보관.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1–2 µg/mL |
| Flow Cytometry (Flow) | 1–2 µg/10^6 cells |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | NA24 |
| Immunogen | GST fusion protein containing the N-terminal part of nucleophosmin fused to 14 amino acids of ALK protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
NPM1 (Nucleophosmin 1, also known as B23, nutramin, NO38) is a ubiquitously expressed phosphoprotein involved in ribosome assembly and transport, cytoplasmic/nuclear trafficking, regulation of DNA polymerase alpha activity, centrosome duplication, and regulation of p53.
It continuously shuttles between the nucleus, cytoplasm, and nucleolus, chaperoning core histones from the nucleus to the cytoplasm. NPM1 binds nucleic acids, prevents protein aggregation, protects enzymes during thermal denaturation, and aids in renaturation of chemically denatured proteins.
NPM1 interacts with tumor-associated chromosome translocations forming fusion proteins such as NPM-ALK, NPM-RAR, and NPM-MLF1. It acts as an interface for oligomerization and oncogenic conversion of these fusion proteins.
Dysfunction of NPM1 is associated with diseases including acute myeloid leukemia and lymphomatoid papulosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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