Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (ISA-3), Super Bright 600, eBioscience
Human ICOS(CD278) 인식 단클론 항체 ISA-3, Super Bright 600 형광체 결합 제품. Flow cytometry에 최적화된 사용 가능. Violet laser(405 nm)로 여기되어 600 nm에서 방출. 4°C 암조건 보관, 고감도 면역세포 분석에 적합.
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Thermo Fisher Scientific CD278 (ICOS) Monoclonal Antibody (ISA-3), Super Bright 600, eBioscience
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Flow Cytometry (Flow) | 5 µL (0.125 µg)/test | View 5 publications |
| Neutralization (Neu) | - | View 1 publication |
Product Specifications
| Item | Description |
|---|---|
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Super Bright™ 600, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ISA-3 |
| Conjugate | Super Bright™ 600 |
| Excitation / Emission Max | 414 / 601 nm |
| Form | Liquid |
| Concentration | 5 µL/Test |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Wet ice |
| RRID | AB_2717070 |
Additional Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- APC-eFluor 780
- Biotin
- Brilliant UV 661
- eFluor 450
- FITC
- Functional Grade
- NovaFluor Red 660
- NovaFluor Red 710
- NovaFluor Yellow 700
- NovaFluor Yellow 730
- PE
- PE-Cyanine5.5
- PE-Cyanine7
- PE-eFluor 610
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 645
- Super Bright 780
- Request custom conjugation
Product Specific Information
The ISA-3 monoclonal antibody reacts with human ICOS (Inducible COStimulatory molecule), also known as H4, CRP-1 and AILIM. ICOS is a T cell-specific activation molecule and a third member of the CD28/CTLA-4 family. It plays a key role in T cell activation and humoral immune responses, particularly in memory B cell and plasma cell generation.
Plate-bound ISA-3 induces production of IL-4, IL-5, IL-10, and other cytokines, but not IL-2. ISA-3 was generated against human ICOS antigen.
Applications Reported: Flow cytometric analysis.
Applications Tested: Pre-diluted and tested on normal human peripheral blood cells. Recommended 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test).
Super Bright 600 is a tandem dye excited by the violet laser (405 nm) and emits at 600 nm. Recommended detection filter: 610/20 bandpass.
When using multiple Super Bright dye-conjugated antibodies, use Super Bright Complete Staining Buffer (Product # SB-4401) to minimize non-specific polymer interactions.
Light Sensitivity: Protect vial and stained samples from light.
Fixation: Samples may be stored up to 3 days at 4°C in the dark using IC Fixation Buffer (Product # 00-8222) or 1-step Fix/Lyse Solution (Product # 00-5333).
Excitation: 405 nm
Emission: 600 nm
Laser: Violet Laser
Super Bright Polymer Dyes are sold under license from Becton, Dickinson and Company.
Target Information
ICOS (CD278) encodes a protein belonging to the CD28 and CTLA-4 receptor family. It functions as a homodimer and is involved in cell-cell signaling, immune response regulation, and cell proliferation. ICOS is associated with disorders such as Immunodeficiency, Common Variable, 1 and Common Variable Immunodeficiency.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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