Thermo Fisher Scientific SR-BI Polyclonal Antibody
SR-BI 단백질을 표적으로 하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, ICC/IF 등 다양한 응용에 적합. 고순도 항원 친화 크로마토그래피 정제. HDL 대사 연구 및 콜레스테롤 관련 생리 연구에 활용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000–1:5,000 | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2.5–5 µg/mL | - |
| Immunohistochemistry (Frozen) (IHC (F)) | 2.5–5 µg/mL | - |
| Immunocytochemistry (ICC/IF) | 1:50–1:1,000 | View 1 publication |
| Flow Cytometry (Flow) | 1:10–1:1,000 | - |
| Immunoprecipitation (IP) | 1:10–1:500 | - |
| Neutralization (Neu) | Assay-Dependent | - |
| in situ PLA (PLA) | Assay-Dependent | - |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mink, Mouse, Non-human primate, Pig, Rabbit, Rat |
| Published Species | Human |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to a region within residues 450–509 of mouse Scavenger Receptor-BI |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2269859 |
Product Specific Information
Suggested positive control: antigen standard for SCARB1 (transient overexpression lysate).
Target Information
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism and their plasma concentrations are inversely correlated with risk for atherosclerosis.
SR-BI binds HDLs and mediates selective uptake of HDL cholesteryl ester.
SR-BI binds HDL with high affinity, is expressed primarily in liver and nonplacental steroidogenic tissues, and mediates selective cholesterol uptake by a distinct mechanism.
In mice, SR-BI plays a key role in determining plasma lipoprotein cholesterol levels and the accumulation of cholesterol stores in the adrenal gland.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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