Thermo Fisher Scientific LAMP1 Monoclonal Antibody (H4A3), PE

Applications

• Flow Cytometry (Flow): 4 µL/1×10⁶ cells
• View 2 publications

Product Specifications

Additional Formats

• Unconjugated
• Alexa Fluor 488
• APC
• Request custom conjugation

Product Specific Information

This antibody recognizes an extracellular/luminal epitope of CD107a, an approximately 100–120 kDa glycoprotein expressed mainly on lysosomal membranes, and also on the plasma membrane.

Target Information

LAMP1 (CD107a, lysosome-associated membrane protein-1) is a major component of the lysosomal membrane. Together with LAMP2, it contributes to lysosome biogenesis and fusion with phagosomes. LAMP1 is a heavily glycosylated type I integral membrane protein with 18 N-linked glycosylation sites, a single transmembrane domain, and a short cytosolic tail.
Upon cell activation, LAMP1 translocates to the plasma membrane via a tyrosine-based motif (YXXI). Mutations affecting this motif alter lysosomal localization, causing cycling between plasma membrane and endosomes.
Cell surface LAMP1 and LAMP2 promote adhesion of PBMCs to vascular endothelium, suggesting a role in inflammation. Increased LAMP1 expression is observed in neurons and glial cells near senile plaques in Alzheimer’s disease, and in immune cells during acute thymic involution. LAMP1 serves as a useful marker for mast cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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