Thermo Fisher Scientific PSMB7 Polyclonal Antibody
PSMB7 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody. Western blot, IHC, IP 등 다양한 응용 가능. Human 및 Mouse 반응성. 항원 친화 크로마토그래피로 정제된 1 mg/mL 액상 항체로, 4°C 보관.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:1,000–1:5,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:1,000–1:5,000 |
| Immunoprecipitation (IP) | Assay-dependent |
Product Specifications
| Specification | Detail |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 150 and 200 of Human Proteasome (Prosome, Macropain) Subunit, Beta Type, 7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Phosphate/tris citrate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections
- Predicted to react with Rat and Bovine based on 100% sequence identity
Target Information
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure composed of four rings of 28 non-identical subunits (two alpha and two beta rings). Proteasomes are widely distributed in eukaryotic cells and cleave peptides via an ATP/ubiquitin-dependent, non-lysosomal pathway.
The immunoproteasome plays a key role in processing class I MHC peptides. The PSMB7 gene encodes a member of the proteasome B-type (T1B) family, a 20S core beta subunit. Expression of this catalytic subunit is downregulated by gamma interferon, and proteolytic processing is required to generate a mature form. This subunit is not present in the immunoproteasome and is replaced by catalytic subunit 2i (proteasome beta 10 subunit).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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