Thermo Fisher Scientific TRPM4 Recombinant Rabbit Monoclonal Antibody (5L6V0)
TRPM4 단백질을 인식하는 토끼 단클론 항체로, Western blot 및 ELISA에 적합합니다. 인체 유래 단백질을 면역원으로 사용하였으며, 고순도의 Protein A 정제 항체입니다. 액상 형태로 제공되며, -20°C에서 보관합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 5L6V0 |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1097–1214 of human TRPM4 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.94 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.3, with 0.05% BSA, 50% glycerol |
| Contains | 0.05% ProClin 300 |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
Product Specific Information
Immunogen Sequence:
RSPQPSSPAL EHFRVYLSKE AERKLLTWES VHKENFLLAR ARDKRESDSE RLKRTSQKVD LALKQLGHIR EYEQRLKVLE REVQQCSRVL GWVAEALSRS ALLPPGGPPP PDLPGSKD
Target Information
Calcium-activated non-selective (CAN) cation channel that mediates membrane depolarization. While activated by increased intracellular Ca²⁺, it is impermeable to it. Mediates transport of monovalent cations (Na⁺, K⁺, Cs⁺, Li⁺), leading to membrane depolarization. Plays a central role in cardiomyocytes, neurons, endocrine pancreas cells, kidney epithelial cells, cochlear hair cells, and others. Participates in T-cell activation by modulating Ca²⁺ oscillations required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries and controls insulin secretion in pancreatic beta-cells. May contribute to pacemaking or irregular electrical activity under Ca²⁺ overload. Affects Th1 and Th2 cell motility and cytokine production via calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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