Thermo Fisher Scientific TPMT Recombinant Rabbit Monoclonal Antibody (4P2U9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:1,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

4P2U9

Immunogen

A synthetic peptide corresponding to a sequence within amino acids 50-150 of human TPMT. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TPMT,uniProtId:P51580-1,ncbiNodeId:9606,antigenRange:50-150,antigenLength:245,antigenImageFileName:MA5-55578_TPMT_P51580-1_Rabbit.svg,antigenImageFileNamePDP:MA5-55578_TPMT_P51580-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.8 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 0.05% BSA, 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Product Specific Information

Immunogen Sequence: KKHLDTFLKG KSGLRVFFPL CGKAVEMKWF ADRGHSVVGV EISELGIQEF FTEQNLSYSE EPITEIPGTK VFKSSSGNIS LYCCSIFDLP RTNIGKFDMI W

Target Information

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. Defects in TPMT are the cause of thiopurine S-methyltransferase deficiency (TPMT deficiency). TPMT is an enzyme involved in the normal metabolic inactivation of thiopurine drugs. These drugs are generally used as immunosupressants or cytotoxic drugs and are prescribed for a variety of clinical conditions including leukemia, autoimmune disease and organ transplantation. Patients with intermediate or no TPMT activity are at risk of toxicity after receiving standard doses of thiopurine drugs and it is shown that inter-individual differences in response to these drugs are largely determined by genetic variation at the TPMT locus.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.