Thermo Fisher Scientific KITLG Monoclonal Antibody (OTI5E9), TrueMAB

Applications

• Western Blot (WB)
  Tested Dilution: 1:4,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Stem Cell Factor (SCF) is the ligand of the c-Kit oncogene, expressed by various structural and inflammatory cells in the airways.
Binding of SCF to the c-Kit receptor triggers receptor homodimerization and activates signaling pathways such as PI-3, PLC-gamma, Jak/STAT, and MAP kinase.
SCF expression induces mast cell survival and promotes the release of histamine, pro-inflammatory cytokines, and chemokines.
Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness — suggesting potential therapeutic relevance in inflammatory diseases such as asthma.
At least two isoforms of SCF are known to exist.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.