Thermo Fisher Scientific KITLG Monoclonal Antibody (OTI5F6), TrueMAB

Applications

• Western Blot (WB): 1:4,000
• Immunohistochemistry (Paraffin) (IHC (P)): 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional round of desalting (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

Stem cell factor (SCF) is the ligand of the c-Kit oncogene, expressed by various structural and inflammatory cells in the airways.
Binding of SCF to the c-Kit receptor induces receptor homodimerization and activates signaling pathways including PI-3, PLC-gamma, Jak/STAT, and MAP kinase.
SCF expression promotes mast cell survival and release of histamine, pro-inflammatory cytokines, and chemokines.
Inhibition of the SCF/c-Kit pathway reduces histamine levels, mast cell and eosinophil infiltration, IL-4 production, and airway hyperresponsiveness — suggesting its potential as a therapeutic target in inflammatory diseases such as asthma.
At least two isoforms of SCF are known to exist.

For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.

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