Thermo Fisher Scientific Podoplanin Polyclonal Antibody
Podoplanin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal 항체입니다. Western blot, IHC, ELISA, IP 등 다양한 응용에 적합하며, 인간 및 생쥐 시료에 반응합니다. 고순도 Affinity chromatography로 정제되어 연구용으로 안정적입니다.
- 카탈로그번호
- PDPN-112AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 80–130 on human Podoplanin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer, pH 7.4–7.8, with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type 1 glycoprotein with a molecular weight of 40–43 kDa. It is expressed in various tumors and normal cells, particularly lymphatic epithelial cells and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells.
As a regulator of lymphatic endothelium, podoplanin plays a role in maintaining the unique shape of podocytes and serves as a ligand for CLEC-2. Its expression correlates with tumors exhibiting invasive and metastatic potential. Podoplanin is involved in cell migration, metastasis formation, and tumor cell invasion. Expression can be induced via Src activation of Cas, and recent studies indicate its presence on Th17 cells. It has been detected on a distinct population of CD4+ cells from human PBMC.
Dysfunction of podoplanin is associated with diseases such as lymphangioma and subglottis neoplasm. It has also been proposed as a marker for lung injury due to its physiological role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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