Thermo Fisher Scientific Podoplanin Polyclonal Antibody
Podoplanin 단백질을 인식하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody입니다. Western blot, IHC, ELISA, IP 등 다양한 응용 가능. 높은 특이성과 재현성을 제공하며, 인체 및 마우스 시료에 반응. 연구용으로만 사용.
- 카탈로그번호
- PDPN-101AP
- 판매단위
- pk
카탈로그
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunohistochemistry (IHC) | 1:50–1:250 |
| ELISA | 1:10,000 |
| Immunoprecipitation (IP) | 1:50–1:250 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide within amino acid region 30–100 of human Podoplanin protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5–1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | Proprietary buffer (pH 7.4–7.8), with 30% glycerol, 0.5% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin-type I glycoprotein with a molecular weight of 40–43 kDa. It is expressed in various tumors and normal cells, notably lymphatic epithelial and follicular dendritic cells. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells and plays a role in maintaining podocyte morphology. It serves as a ligand for CLEC-2, and its expression correlates with tumor invasiveness and metastatic potential. Podoplanin participates in cell migration, metastasis formation, and tumor invasion, and its expression is induced via Src activation of Cas. Recent studies indicate podoplanin presence on Th17 cells and a distinct subset of CD4+ cells from human PBMC. Dysfunction of podoplanin is associated with diseases such as lymphangioma and subglottic neoplasm, and it is proposed as a marker for lung injury due to its physiological role.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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