Thermo Fisher Scientific GSK3 alpha/beta Monoclonal Antibody (4G-1E)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA3-038 detects GSK3 alpha/beta in Human, Mouse, Rat, Canine, and Non-human primate samples.
Immunogen is a synthetic peptide corresponding to residues 203–219 of drosophila GSK-3, which is highly conserved across multiple species.

Target Information

Glycogen synthase kinase-3 (GSK3) is a protein kinase originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism.
It is involved in diverse cellular functions such as protein synthesis, cell proliferation, differentiation, microtubule assembly/disassembly, and apoptosis.

GSK3’s substrate specificity requires a phosphoserine or phosphotyrosine four residues C-terminal to the phosphorylation site.
Two isoforms exist: GSK3 alpha and GSK3 beta, both regulated via phosphorylation.
Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by PKB leads to inactivation, while activation occurs via Tyr216 (Tyr279 in GSK3 alpha).

Activated GSK3 beta phosphorylates cellular proteins including p53, c-Myc, c-Jun, HSF-1, and cyclin D1.
It also phosphorylates tau protein, implicated in Alzheimer’s disease progression.

For Research Use Only. Not for use in diagnostic procedures or resale without authorization.

제품 이미지