Thermo Fisher Scientific GSK3 alpha/beta Monoclonal Antibody (4G-1E)
GSK3 alpha/beta 단백질을 검출하는 Thermo Fisher Scientific의 단클론 항체로, Human, Mouse, Rat, Dog 등 다양한 종에 반응함. Western blot, IHC, ICC/IF, Flow cytometry 등 다중 응용 가능. 합성 펩타이드 면역원 기반, 비결합형 액상 형태로 연구용에 적합.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:1,000 | View 2 publications |
| Immunohistochemistry (IHC) | - | View 1 publication |
| Immunocytochemistry (ICC/IF) | 1:1,000 | - |
| Flow Cytometry (Flow) | 1:100 | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
| RNA Immunoprecipitation (RIP) | Assay-dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Dog, Fruit fly, Human, Mouse, Non-human primate, Rat |
| Published Species | Fruit fly, Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 4G-1E |
| Immunogen | Synthetic peptide corresponding to residues 203–219 of drosophila GSK-3 coupled to ovalbumin: KQLLHGEPNVSYICSRY |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | Not determined |
| Storage Buffer | Ascites |
| Contains | 0.05% sodium azide |
| Storage Conditions | -20°C, Avoid freeze/thaw cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2608651 |
Product Specific Information
MA3-038 detects GSK3 alpha/beta in Human, Mouse, Rat, Canine, and Non-human primate samples.
Immunogen is a synthetic peptide corresponding to residues 203–219 of drosophila GSK-3, which is highly conserved across multiple species.
Target Information
Glycogen synthase kinase-3 (GSK3) is a protein kinase originally identified as a regulator of glycogen synthase, a key enzyme in glycogen metabolism.
It is involved in diverse cellular functions such as protein synthesis, cell proliferation, differentiation, microtubule assembly/disassembly, and apoptosis.
GSK3’s substrate specificity requires a phosphoserine or phosphotyrosine four residues C-terminal to the phosphorylation site.
Two isoforms exist: GSK3 alpha and GSK3 beta, both regulated via phosphorylation.
Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) by PKB leads to inactivation, while activation occurs via Tyr216 (Tyr279 in GSK3 alpha).
Activated GSK3 beta phosphorylates cellular proteins including p53, c-Myc, c-Jun, HSF-1, and cyclin D1.
It also phosphorylates tau protein, implicated in Alzheimer’s disease progression.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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