Thermo Fisher Scientific CD11b Monoclonal Antibody (2LPM19c)
인간 CD11b 단백질을 검출하는 마우스 단클론 항체로, IHC(F), Flow Cytometry, Inhibition Assay 등에 사용 가능. 비결합형 액상 형태이며 PBS/BSA 완충액에 보관. 연구용으로만 사용.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: Assay-dependent
Flow Cytometry (Flow)
- Tested Dilution: Assay-dependent
Inhibition Assays (IA)
- Tested Dilution: Not specified
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2LPM19c |
| Immunogen | Purified C3bi Receptor |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | IgG fraction |
| Storage Buffer | PBS, pH 7.2, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2129132 |
Product Specific Information
MA1-91659 detects CD11b from human samples.
Target Information
CD11b (integrin alpha-M, ITGAM, integrin alpha-X, ITGAX) is a 165 kDa adhesion molecule that associates non-covalently with integrin beta-2 (CD18).
The CD11b/CD18 heterodimeric complex is also known as integrin alpha-M beta-2, Mac-1, and CR3 (complement receptor 3).
CD11b is expressed on:
- Monocytes/macrophages
- Granulocytes
- Activated lymphocytes
- Subsets of NK cells and dendritic cells
- Microglia in the brain
CD11b/CD18 functions as the receptor for ICAM-1 (CD54), ICAM-2 (CD102), ICAM-4 (CD242), CD14, CD50, CD23, heparin, iC3b, fibrinogen, and Factor X.
These adhesions are critical for cell-cell and cell-matrix interactions.
Expression levels:
- 8% of spleen cells
- 44% of bone marrow cells
- <1% of thymocytes
CD11b is commonly used as a microglial marker in nervous tissue. Expression increases during monocyte maturation and varies across tissue macrophages.
Peritoneal macrophages express higher levels of CD11b than splenic macrophages.
Diseases associated with CD11b dysfunction include:
- Systemic lupus erythematosus
- ITGAM-related susceptibility to systemic lupus erythematosus
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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