Thermo Fisher Scientific Alkaline Phosphatase (Placental)/PLAP (Germ Cell Tumor Marker) Monoclonal Antibody (rALP/870)
인체 PLAP(Germ Cell Tumor Marker)을 인식하는 Mouse 모노클로날 항체로, Western Blot 및 Immunohistochemistry에 적합. Recombinant full-length ALPP 항원을 면역원으로 사용. 단백질 A/G 정제, 액상 형태, 4°C 보관. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2 µg/mL |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rALP/870 |
| Immunogen | Recombinant full-length human ALPP protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, do not freeze |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Target Information
Placental Alkaline Phosphatase (PLAP) plays an important role in the regulation of specific inflammatory disease processes. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney forms.
PLAP reacts with a membrane-bound isoenzyme (Regan and Nagao type) occurring in the placenta during the third trimester of gestation. It is useful in identifying testicular germ cell tumors. Unlike germ cell tumors, PLAP-positive somatic cell tumors uniformly express epithelial membrane antigen (EMA).
A proposed function of PLAP is matrix mineralization; however, mice lacking a functional form of this enzyme show normal skeletal development. PLAP has been linked to hypophosphatasia, a disorder characterized by hypercalcemia and skeletal defects. The severity and onset of hypophosphatasia vary depending on the specific mutation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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