Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (rBP53-12)
p53 종양억제 단백질을 인식하는 Thermo Fisher Scientific의 단클론 항체. 인간 및 다양한 종에 반응하며, WB 및 IHC 등 여러 응용에 적합. 단백질 A/G로 정제된 액상 형태, 보존제 없음. 연구용으로만 사용 가능.
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Thermo Fisher Scientific p53 Tumor Suppressor Protein Monoclonal Antibody (rBP53-12)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1–2 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent |
| Immunohistochemistry (PFA fixed) (IHC (PFA)) | 1–2 µg/mL |
| Peptide Array (Array) | Assay-dependent |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Dog, Chicken, Hamster, Human, Non-human primate |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | rBP53-12 |
| Immunogen | Recombinant human wild-type p53 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Product Specific Information
- Does not react with Mouse or Rat.
Target Information
The tumor suppressor protein p53 is a sequence-specific transcription factor activated by cellular stress. It mediates cell cycle arrest or apoptosis in response to DNA damage or nucleotide starvation. p53 up-regulation activates transcription of genes such as p21waf1, leading to G1 or G2/M arrest. Structurally, p53 includes an N-terminal transactivation domain, central DNA-binding domain, oligomerization domain, and C-terminal regulatory domain.
Phosphorylation at Ser15 is critical for activation and stabilization, while Ser392 phosphorylation correlates with tumor formation. p53 helps prevent proliferation of damaged cells and acts as an anticancer agent. It is also linked to aging, oxidative stress, and cognitive function deficits. Normally expressed at low levels, p53 is highly expressed in transformed cells, contributing to malignancy. Mutations in p53 disrupt DNA binding and tumor suppressor function. TP53 gene alterations occur as somatic or germline mutations, including in Li-Fraumeni syndrome.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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