Thermo Fisher Scientific SGO2 Polyclonal Antibody
Rabbit polyclonal antibody targeting human SGO2 (Shugoshin-like 2). Validated for WB and IP applications. Unconjugated, liquid form at 0.20 mg/mL concentration. Supports centromeric cohesin protection studies in meiosis research.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000–1:10,000
Immunoprecipitation (IP)
- Tested Dilution: 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 750 and 800 of Human shugoshin-like 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes during meiosis I. Plays a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, maintains centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Essential for accurate gametogenesis. May act by targeting PPP2CA to centromeres, leading to cohesin dephosphorylation. Required for recruiting KIF2C to the inner centromere and correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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