Thermo Fisher Scientific SGO2 Polyclonal Antibody
인간 SGOL2 단백질을 인식하는 Rabbit Polyclonal 항체로 Western blot 및 Immunoprecipitation에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 액상 형태로 1 mg/mL 농도 제공. 4°C에서 보관하며 연구용으로만 사용.
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Applications
Western Blot (WB)
- Assay-dependent
Immunoprecipitation (IP)
- 2–5 µg/mg lysate
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 175 and 225 of Human shugoshin-like 2 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | Tris citrate/phosphate, pH 7–8 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt.
Target Information
Cooperates with PPP2CA to protect centromeric cohesin from separase-mediated cleavage in oocytes during meiosis I. Plays a crucial role in protecting REC8 at centromeres from cleavage by separase. During meiosis, it maintains centromeric cohesion complexes until the metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Essential for accurate gametogenesis. May act by targeting PPP2CA to centromeres, leading to cohesin dephosphorylation. Required for recruiting KIF2C to the inner centromere and correcting defective kinetochore attachments. Involved in centromeric enrichment of AUKRB in prometaphase. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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