Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), Biotin, eBioscience
Human IL-17A 인식 및 중화용 마우스 단클론 항체로, Biotin 결합형. ELISA, Flow Cytometry, Immunohistochemistry 등 다양한 어플리케이션에서 사용 가능. 염증성 질환 연구에 적합하며 높은 특이성과 재현성을 제공.
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Thermo Fisher Scientific IL-17A Monoclonal Antibody (eBio64DEC17), Biotin, eBioscience™
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | 3 |
| Immunohistochemistry (Paraffin) (IHC (P)) | - | 1 |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-Dependent | - |
| Immunocytochemistry (ICC/IF) | - | 3 |
| Flow Cytometry (Flow) | - | 21 |
| ELISA | 0.5–2 µg/mL | 7 |
| Neutralization | - | 1 |
| Radioimmune Assays (RIA) | - | 1 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Hamster, Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio64DEC17 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_494044 |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Conjugate Formats
- Unconjugated
- Alexa Fluor 488
- APC
- APC-eFluor 780
- Brilliant UV 563
- Brilliant UV 737
- Brilliant UV 805
- Brilliant Violet 605
- Brilliant Violet 786
- eFluor 450
- eFluor 506
- eFluor 660
- FITC
- PE
- PE-Cyanine7
- PE-eFluor 610
- PerCP-Cyanine5.5
- Custom conjugation available upon request
Product Specific Information
The eBio64DEC17 antibody reacts with human IL-17A and functions as a neutralizing antibody.
IL-17A is a CD4+ T cell-derived cytokine involved in inflammatory responses and is elevated in rheumatoid arthritis, asthma, multiple sclerosis, psoriasis, and transplant rejection.
Human IL-17A exists as glycosylated 20–30 kDa homodimers produced by activated CD4+ T-cells. It enhances ICAM-1 expression in fibroblasts and stimulates epithelial, endothelial, or fibroblastic cells to secrete IL-6, IL-8, G-CSF, and PGE2. In fibroblasts, IL-17A supports CD34+ progenitor proliferation and neutrophil maturation.
IL-23-dependent Th17 cells produce IL-17A via a distinct differentiation pathway from Th1 and Th2 cells. IFN-γ and IL-4 negatively regulate Th17 generation.
The eBio64DEC17 antibody identifies the same intracellular population as eBio64CAP17 in co-staining experiments.
It is validated for use as a detection antibody in ELISA and ELISPOT assays for human IL-17A, typically used at 0.5–2.0 µg/mL in sandwich ELISA with eBio64CAP17 as capture antibody and recombinant IL-17A as standard.
Target Information
Interleukin-17A (IL-17A, CTLA-8) is a CD4+ T cell-derived cytokine promoting inflammatory responses and elevated in autoimmune and inflammatory diseases.
It is a 32 kDa disulfide-linked homodimer (136 amino acids) signaling through IL-17R/CDw217. IL-17A regulates NF-κB and MAPK activities, stimulates IL-6 and COX-2 expression, and enhances nitric oxide production.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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