Thermo Fisher Scientific PGRP-1b Monoclonal Antibody (186C426)
Human PGRP-1b 단백질을 인식하는 mouse IgG1 단클론 항체로, WB, ICC/IF, Flow Cytometry에 사용 가능. 단백질 G로 정제된 액상 형태이며, 0.5 mg/mL 농도. 인체 면역 반응 연구용으로 적합.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 2 µg/mL |
| Immunocytochemistry (ICC/IF) | 1:10–1:2,000 |
| Flow Cytometry (Flow) | Assay-Dependent |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 186C426 |
| Immunogen | Synthetic peptide, KLH-conjugated, corresponding to residues 95–110 of human PGRP-1b |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 0.5% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2161404 |
Product Specific Information
Suggested positive control: human brain tissue, human brain protein.
Target Information
The primary immune recognition is based on structures common among invading pathogens. Bacterial surface molecules, such as lipopolysaccharide (LPS) and peptidoglycan (PGN), are known to elicit immune reactions ranging from cytokine release to fever. Recently, a family of proteins called peptidoglycan recognition protein (PGRP) has been identified in mouse and human that binds to peptidoglycans expressed on Gram-positive bacteria.
Peptidoglycan (PGN) is an essential cell wall component of virtually all bacteria and is therefore an excellent target for recognition by the eukaryotic innate immune system. The PGRPs (PGRP-L, PGRP-S, PGRP-Ia, and PGRP-Iβ) define a new family of human pattern recognition molecules. PGRP-L is primarily expressed in the liver, which participates in host defenses by producing acute phase proteins in response to infections and by clearing microorganisms from blood.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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