Thermo Fisher Scientific DFFB Monoclonal Antibody (36A349)
DFFB 단백질을 인식하는 Mouse IgG 단클론 항체로 Western blot에 최적화됨. Human 및 Mouse 시료 반응성. 0.5 mg/mL 농도의 액상 형태, Protein G로 정제됨. 세포 사멸 연구용으로 적합.
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Thermo Fisher Scientific DFFB Monoclonal Antibody (36A349)
Applications
- Western Blot (WB)
Tested Dilution
- 1:100–1:2,000
Species Reactivity
- Human
- Mouse
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 36A349 |
| Immunogen | Synthetic peptide corresponding to residues 205–222 of human DFF40 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein G |
| Storage buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2230598 |
Target Information
Caspase-activated DNase (CAD) cleaves chromosomal DNA during apoptosis. Apoptosis, a cell death process that removes toxic or useless cells during mammalian development, can be induced by various stimuli including TNF family death factors, UV irradiation, anticancer drugs, and survival factor deprivation.
CAD exists as a complex with its inhibitor, ICAD, which assists in proper folding and inhibits DNase activity. Upon activation, caspases cleave ICAD, releasing CAD to enter the nucleus and cleave chromosomal DNA.
The apoptotic process is regulated by a balance between pro- and anti-apoptotic proteins of the Bcl-2 family, heat shock proteins, and inhibitors of apoptosis proteins (IAPs). Fourteen caspase family members have been identified, seven of which mediate apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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