Thermo Fisher Scientific brat Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: Assay-dependent

ELISA

• Tested Dilution: Assay-dependent

Product Specifications

Target Information

A NHL-domain family protein that functions as a translational repressor to inhibit cell proliferation (PubMed:11274060).
Plays a central role in translation repression of hb mRNA by being recruited by nanos (nos) and pum to the Nanos Response Element (NRE), a 16 bp sequence in the hb mRNA 3'-UTR (PubMed:11274060).
Likely recruited by other proteins to repress translation of other mRNAs in different tissues (PubMed:11274060).
Involved in regulation of ribosomal RNA synthesis and cell growth (PubMed:11807032).
Participates in abdominal segmentation and imaginal disk development (PubMed:11274060).
During neuroblast division, segregates asymmetrically and inhibits self-renewal of one of the two daughter cells (PubMed:16564014).
Together with the transcription factor prospero, ensures that one daughter cell stops growing, exits the cell cycle, and differentiates into neurons, possibly by modulating dm function in ganglion mother cells (PubMed:11807032, PubMed:16564014).
Restricts developmental potential of type II intermediary neuronal progenitor (INP) cells, playing a role in proliferation and maturation of neuroblasts (PubMed:24550111, PubMed:14561773, PubMed:22143802, PubMed:18342578).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.