Thermo Fisher Scientific SOX-1 Polyclonal Antibody
SOX-1 단백질을 인식하는 Rabbit Polyclonal Antibody로 인간 및 생쥐 시료에 반응. Western blot과 IHC(Paraffin) 실험에 사용 가능. 항원 친화 크로마토그래피로 정제되었으며, 안정적인 PBS 버퍼에 보존. 신경 발달 및 전사 조절 연구에 적합.
- 판매단위
- pk
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide derived from N-terminus of Human SOX-1 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Mouse embryonic brain
- Cellular location: Nuclear
Target Information
SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain.
SOX1 promotes neuronal cell fate determination and differentiation through multiple pathways. It modulates LINE retroposons promoter activity and is involved in the development of the central nervous system, including neural and lens development.
SOX1 binds directly to the HES1 promoter to suppress transcription and attenuate Notch signaling. It also binds to beta-catenin to suppress beta-catenin-mediated TCF/LEF signaling, potentially attenuating WNT signaling.
Expression of SOX1 is mainly in embryonic tissues and moderately in brain.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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