Thermo Fisher Scientific DCC Polyclonal Antibody
DCC 단백질의 C-말단 펩타이드에 특이적인 Rabbit Polyclonal Antibody로 인간 시료에 반응합니다. Western blot 및 IHC(P) 적용 가능. 항원 친화 크로마토그래피로 정제된 액상형 시약이며, 뇌 조직 양성 대조로 사용됩니다. 연구용 전용 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the C-terminus (within 1380–1447aa) of Human DCC protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Brain tissue
- Cellular location: Cell Membrane
Target Information
This gene encodes a netrin 1 receptor. The transmembrane protein is a member of the immunoglobulin superfamily of cell adhesion molecules, and mediates axon guidance of neuronal growth cones towards sources of netrin 1 ligand.
The cytoplasmic tail interacts with the tyrosine kinases Src and focal adhesion kinase (FAK, also known as PTK2) to mediate axon attraction.
The protein partially localizes to lipid rafts, and induces apoptosis in the absence of ligand.
It functions as a tumor suppressor and is frequently mutated or downregulated in colorectal cancer and esophageal carcinoma.
Usage Note
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일: 601-460_DCC_P43146-1_Rabbit.svg, 601-460_DCC_P43146-1_Rabbit_PDP.jpeg)
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