Thermo Fisher Scientific LSD1 Monoclonal Antibody (1B2E5)
LSD1 단백질을 검출하기 위한 Thermo Fisher Scientific의 단일클론 항체로, WB, IHC, ELISA에 사용 가능. 인간, 마우스, 영장류 시료에 반응하며, 비결합형 액상 형태로 제공. 장기 보관 시 -20°C에서 냉동 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| ELISA | 1:10,000 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Non-human primate |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 1B2E5 |
| Immunogen | Purified recombinant fragment of human LSD1 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10985261 |
Product Specific Information
MA5-15273 targets LSD1/AOF2 in indirect ELISA, IHC, and WB applications and shows reactivity with human, mouse, and non-human primate samples.
The immunogen is a purified recombinant fragment of human LSD1 expressed in E. coli.
MA5-15273 detects LSD1/AOF2, which has a predicted molecular weight of approximately 93 kDa.
Target Information
LSD1 is a histone demethylase that specifically demethylates Lys-4 of histone H3, a marker for epigenetic transcriptional activation, thereby acting as a corepressor.
It contains a SWIRM domain, a FAD-binding motif, and an amine oxidase domain. LSD1 functions as part of several histone deacetylase complexes and silences genes through histone demethylation.
The enzyme oxidizes substrates via FAD to generate imines that are subsequently hydrolyzed. LSD1 demethylates mono- and tri-methylated Lys-4 of histone H3 and may play a role in neuronal gene repression.
It requires RCOR1/CoREST for nucleosome demethylation activity and may also demethylate Lys-9 of histone H3, leading to derepression of androgen receptor target genes.
Mutations in this gene can cause cleft palate, psychomotor retardation, and distinctive facial features.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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