Thermo Fisher Scientific FGF2 Monoclonal Antibody (2H5G2C11)
FGF2 단백질을 인식하는 Mouse IgG 단클론 항체로, Human 샘플에 반응합니다. WB, IHC, ICC, ELISA 등 다양한 응용에 사용 가능하며, 고순도 재조합 FGF2 항원으로 제작되었습니다. 액상 형태로 4°C 또는 -20°C 보관이 권장됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1:500–1:2,000 | - |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 | - |
| Immunocytochemistry (ICC/IF) | 1:100 | - |
| ELISA | 1:10,000 | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2H5G2C11 |
| Immunogen | Purified recombinant fragment of FGF2 expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage Buffer | Ascites |
| Contains | 0.03% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_10983372 |
Product Specific Information
MA5-15276 targets FGF2 in indirect ELISA, IHC, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of FGF2 expressed in E. coli.
Target Information
FGF2 (fibroblast growth factor basic, FGFb) is a member of the fibroblast growth factor family. It interacts with high-affinity transmembrane receptors to regulate cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions:
- 18 kDa isoform: predominantly cytosolic, acts through cell surface receptors
- 22, 22.5, 24, and 34 kDa isoforms: nuclear, may signal independently of receptor pathways
In humans, the gene is located on chromosome 4q. FGF2 is involved in limb and nervous system development, wound healing, and tumor growth.
The mRNA includes multiple polyadenylation sites and can be translated from non-AUG and AUG initiation codons, producing five distinct isoforms.
CUG-initiated isoforms are nuclear and mediate intracrine effects, while AUG-initiated forms are cytosolic and mediate paracrine and autocrine signaling.
FGF2 dysfunction is associated with diseases such as Kaposi Sarcoma and corneal neovascularization.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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