Thermo Fisher Scientific FGF2 Monoclonal Antibody (2H5G2C11)

Applications and Tested Dilution

Product Specifications

Product Specific Information

MA5-15276 targets FGF2 in indirect ELISA, IHC, and WB applications and shows reactivity with Human samples.
The immunogen is a purified recombinant fragment of FGF2 expressed in E. coli.

Target Information

FGF2 (fibroblast growth factor basic, FGFb) is a member of the fibroblast growth factor family. It interacts with high-affinity transmembrane receptors to regulate cell proliferation and tissue neovascularization.
FGF2 exists as five isoforms with distinct intracellular localizations and functions:

• 18 kDa isoform: predominantly cytosolic, acts through cell surface receptors
• 22, 22.5, 24, and 34 kDa isoforms: nuclear, may signal independently of receptor pathways

In humans, the gene is located on chromosome 4q. FGF2 is involved in limb and nervous system development, wound healing, and tumor growth.
The mRNA includes multiple polyadenylation sites and can be translated from non-AUG and AUG initiation codons, producing five distinct isoforms.
CUG-initiated isoforms are nuclear and mediate intracrine effects, while AUG-initiated forms are cytosolic and mediate paracrine and autocrine signaling.
FGF2 dysfunction is associated with diseases such as Kaposi Sarcoma and corneal neovascularization.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.