Thermo Fisher Scientific MMP9 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

PA5-16509 targets MMP-9 (92 kDa Collagenase IV) in Western blot applications and shows reactivity with Guinea Pig and Human samples.
The immunogen is a synthetic peptide from the middle region of human MMP-9.

Target Information

MMP9 (matrix metallopeptidase 9, also known as GELB or CLG4B) is a zinc- and calcium-dependent endopeptidase that degrades extracellular matrix proteins.
It is secreted as a 92 kDa zymogen and activated to an 82 kDa enzyme. MMP9 contains a gelatin-binding domain with three fibronectin type II units, a catalytic zinc-binding site, a proline-rich collagen-homologous domain, and a hemopexin-like domain.

MMP9 is produced by various cell types including monocytes, macrophages, neutrophils, keratinocytes, fibroblasts, osteoclasts, and endothelial cells. It plays key roles in:

• Inflammatory responses
• Tissue remodeling and wound healing
• Tumor growth and metastasis

MMP9 contributes to skin carcinogenesis and degrades type IV and V collagens. Studies indicate its involvement in IL-8-induced mobilization of hematopoietic progenitor cells and tumor-associated tissue remodeling. Elevated MMP9 levels are linked to progression of idiopathic atrial fibrillation and aortic aneurysm.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.