Thermo Fisher Scientific Cyclin A Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

5-10 µg/mL

View 4 publications 4 publications

Immunohistochemistry (IHC)

-

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100

-

Immunocytochemistry (ICC/IF)

-

View 1 publication 1 publication

Immunoprecipitation (IP)

10 µg/mL

-

Product Specifications

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from the C-terminus of human cyclin A if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Cyclin A,uniProtId:P20248-1,ncbiNodeId:9606,antigenRange:432,antigenLength:432,antigenImageFileName:PA5-16519_Cyclin_A_P20248-1_Rabbit.svg,antigenImageFileNamePDP:PA5-16519_Cyclin_A_P20248-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

4° C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_10981630

Product Specific Information

PA5-16519 targets Cyclin A in IHC (P), IP, and WB applications and shows reactivity with mouse, Rat, and Human samples.

The PA5-16519 immunogen is a synthetic peptide from the C-terminus of human cyclin A.

Target Information

The critical role that the family of regulatory proteins known as cyclins play in eukaryotic cell cycle regulation is well established. The best-characterized cyclin complex is the mitotic cyclin B/Cdc2 p34 kinase, the active component of maturing promoting factor. Cyclin A accumulates prior to cyclin B in the cell cycle, appears to be involved in control of S phase and has been shown to associate with cyclin-dependent kinase-2 (Cdk2). In addition, cyclin A has been implicated in cell transformation and is found in complexes with E1A, transcription factors DRTF1 and E2F and retinoblastoma protein, p110. A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. It has been proposed that cyclin A1 can associate with Cdk2, p39 and Cdc2 p34.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.