Thermo Fisher Scientific TIRAP Polyclonal Antibody
TIRAP 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체로, Western blot, IHC, IP 등 다양한 응용에 사용 가능. 비결합형 액상 형태로 제공되며, -20°C에서 보관. 연구용으로만 사용 가능.
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- PA112815
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Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 0.5–2.0 µg/mL | View 1 publication |
| Immunohistochemistry (Paraffin) (IHC (P)) | Assay-dependent | - |
| Immunoprecipitation (IP) | - | View 1 publication |
Product Specifications
| Category | Specification |
|---|---|
| Published species | Not Applicable |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to 15 residues near the C-terminus of mouse TIRAP |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2205503 |
Product Specific Information
A suggested positive control for this product is liver, kidney, spleen, skeletal muscle, or heart lysate.
Target Information
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors.
In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-κB and MAP kinase activation, suggesting that TIRAP is also involved in TLR4 signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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