Thermo Fisher Scientific TIRAP Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

0.5-2.0 µg/mL

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Immunohistochemistry (Paraffin) (IHC (P))

Assay-dependent

-

Immunoprecipitation (IP)

-

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Product Specifications

Published species

Not Applicable

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to 15 residues near the C-terminus of mouse TIRAP. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:TIRAP,uniProtId:Q99JY1-1,ncbiNodeId:10090,antigenRange:241,antigenLength:241,antigenImageFileName:PA1-12815_TIRAP_Q99JY1-1_Rabbit.svg,antigenImageFileNamePDP:PA1-12815_TIRAP_Q99JY1-1_Rabbit_PDP.jpeg,sortOrder:2}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2205503

Product Specific Information

A suggested positive control for this product is liver, kidney, spleen, skeletal muscle or heart lysate.

Target Information

Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. These proteins act through adaptor molecules such as TIRAP and MyD88 to activate various kinases and transcription factors. In TIRAP-deficient mice, TLR signaling in response to TLR2 ligands (using either TLR1 and TLR6 as co-receptors) is totally abolished, suggesting that MyD88 and TIRAP work together and are both required for TLR2 signaling. Furthermore, these mice are also resistant to the toxic effects of LPS and show defects in NF-βB and MAP kinase activation, suggesting that TIRAP is also involed in TLR4 signaling.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.