Thermo Fisher Scientific TLR7 Polyclonal Antibody
TLR7 단백질 검출용 Rabbit Polyclonal 항체로, Western Blot 및 Immunocytochemistry에 사용 가능. Daudi 세포 용해물을 양성 대조군으로 권장. TLR7의 병원체 인식 및 선천면역 활성화 연구에 적합. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.5–2 µg/mL |
| Immunocytochemistry (ICC/IF) | Assay-dependent |
Product Specifications
| 항목 | 내용 |
|---|---|
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to 14 residues near the middle of mouse TLR7 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_1087927 |
Product Specific Information
A suggested positive control for this product is Daudi cell lysate.
Target Information
TLR7 is a 10 amino acid long highly conserved membrane protein belonging to the Toll-like receptor (TLR) family with 27 LRR (leucine-rich) repeats and a TIR domain.
TLR7 plays a fundamental role in pathogen recognition and activation of innate immunity. It is activated by infections with single-stranded RNA viruses, including influenza virus and vesicular stomatitis virus (VSV).
TLR7 is predominantly expressed in lung, placenta, and spleen, and lies in close proximity to another family member, TLR8.
TLR7 also acts via MyD88 and TRAF6, leading to NF-kappaB activation, cytokine secretion, and the inflammatory response.
It recognizes pathogen-associated molecular patterns (PAMPs) expressed on infectious agents, mediating cytokine production necessary for effective immunity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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