Thermo Fisher Scientific PAG1 Recombinant Rabbit Monoclonal Antibody (ARC2448)
PAG1 단백질을 인식하는 recombinant rabbit monoclonal 항체로, Western blot 및 ELISA에 적합합니다. Human, Mouse, Rat 시료에 반응하며, 고순도 affinity chromatography로 정제되었습니다. 안정적인 액상 형태로 -20°C에서 보관 가능합니다.
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- MA537900
- 판매단위
- pk
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | ARC2448 |
| Immunogen | A synthetic peptide corresponding to a sequence within amino acids 333–432 of human PAG1 (Q9NWQ8) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol, 0.05% BSA |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2897820 |
Product Specific Information
- Positive Samples: Raji, SH-SY5Y, Mouse brain, Mouse spleen, Rat lung, Rat brain, Rat spleen
- Immunogen sequence:
SLTVPESTYT SIQGDPQRSP SSCNDLYATV KDFEKTPNST LPPAGRPSEE PEPDYEAIQT LNREEEKATL GTNGHHGLVP KENDYESISD LQQGRDITRL
Target Information
PAG (phosphoprotein associated with GEMs), also known as Cbp (Csk-binding protein), is a ubiquitously expressed 46 kDa transmembrane adaptor protein present in membrane rafts (glycosphingolipid-enriched microdomains), which migrates on SDS-PAGE gels as an 80 kDa molecule. Following tyrosine phosphorylation by Src family kinases, PAG binds and activates the protein tyrosine kinase Csk, a major negative regulator of the Src family kinases.
Signaling via the B-cell receptor or high-affinity IgE receptor (FcepsilonRI) leads to increased PAG tyrosine phosphorylation and Csk binding, while T cell receptor signaling causes PAG dephosphorylation, loss of Csk binding, and increased activation of Lck.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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