Thermo Fisher Scientific NOD2 Monoclonal Antibody (2D9)
Thermo Fisher Scientific의 NOD2 Monoclonal Antibody (Clone 2D9)은 인간 및 생쥐 NOD2 단백질을 인식하는 고특이성 항체입니다. WB, IHC, ICC, Flow, IP 등 다양한 응용에 적합하며, Protein G로 정제된 액상 형태로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution | Notes |
|---|---|---|
| Western Blot (WB) | 1:100–1:2,000 | |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:500 | |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | |
| Immunocytochemistry (ICC/IF) | 1:50–1:500 | 1 publication available |
| Flow Cytometry (Flow) | Assay-dependent | |
| Immunoprecipitation (IP) | 1:10–1:500 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2D9 |
| Immunogen | Recombinant human NOD2 protein corresponding to residues 28–301 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_568643 |
Product Specific Information
The target sequence has 92% sequence homology with primate.
Target Information
NOD2 is a member of the apoptosis-regulating protein family that includes caspase recruitment domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide-binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs).
NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). It plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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