Thermo Fisher Scientific NOD2 Monoclonal Antibody (2D9)

Applications

Tested Dilution

Publications

Western Blot (WB)

1:100-1:2,000

-

Immunohistochemistry (Paraffin) (IHC (P))

1:10-1:500

-

Immunohistochemistry (Frozen) (IHC (F))

Assay-Dependent

-

Immunocytochemistry (ICC/IF)

1:50-1:500

View 1 publication 1 publication

Flow Cytometry (Flow)

Assay-Dependent

-

Immunoprecipitation (IP)

1:10-1:500

-

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

2D9

Immunogen

Recombinant human NOD2 protein corresponding to residues 28-301. if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:NOD2,uniProtId:Q9HC29-1,ncbiNodeId:9606,antigenRange:28-301,antigenLength:1040,antigenImageFileName:MA1-16611_NOD2_Q9HC29-1_House_mouse.svg,antigenImageFileNamePDP:MA1-16611_NOD2_Q9HC29-1_House_mouse_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein G

Storage buffer

PBS

Contains

0.05% sodium azide

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_568643

Product Specific Information

The target sequence has 92% sequence homology with primate.

Target Information

NOD2 is a member of the apoptosis regulating protein family that includes caspase recruitment-domains, as well as Apaf-1 and NOD1. It contains two N-terminal CARDs, a nucleotide binding domain (NBD), and multiple C-terminal leucine-rich repeats (LRRs). NOD2 is expressed in monocytes (whereas NOD1 is expressed in multiple tissues). NOD2 plays a role in regulating NF-kappaB, acts as an intracellular receptor for bacterial lipopolysaccharides, and contributes to inflammatory bowel disease (IBD) and Crohn`s disease.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.